How is Ovarian Malignancy Diagnosed?

Research shows that 3% of women receive a uterine malignancy diagnosis, whereas over 65,000 people experience it annually. However, the complex nature of this illness and the symptoms can make it challenging for healthcare professionals to provide a quick diagnosis. In today’s blog, we’ll discuss what uterine malignancy is and how your doctor delivers an accurate diagnosis:

Did you know that ovarian cancer ranks as the second most common gynecologic cancer in the United States, causing more fatalities than any other cancer in the female reproductive system? The alarming truth shows the importance of understanding how this stealthy disease is diagnosed.

In this blog, we’ll break down the basics of ovarian cancer diagnosis. By shedding light on the methods used by healthcare professionals, we aim to empower you with knowledge about early detection.

Common Symptoms of Ovarian Cancer

Here are some of the most common symptoms of ovarian malignancy that you can spot early on:

  1. Abdominal Pain or Pressure: Persistent discomfort or pain in the pelvic area or abdomen.
  2. Bloating: Unexplained and persistent bloating, especially if it is accompanied by changes in eating habits or feeling full quickly.
  3. Changes in Bowel Habits: Alterations in bowel movements, such as constipation or diarrhea, without a clear cause.
  4. Frequent Urination: Urgency to urinate or increased frequency, often resembling symptoms of a urinary tract infection.
  5. Loss of Appetite or Feeling Full Quickly: A sudden decrease in appetite or the sensation of feeling full after eating only a small amount.
  6. Unexplained Weight Loss: Significant and unintentional weight loss that cannot be attributed to changes in diet or exercise.

Initial Screening and Assessment

Routine Pelvic Exams

A routine pelvic exam is a standard gynecological procedure where a healthcare provider checks for any abnormalities in a woman’s reproductive organs, including the ovaries. During the exam, the healthcare professional manually feels the pelvic area for any irregularities or masses. It’s a quick and non-invasive way to detect changes in the size or shape of the ovaries.

Transvaginal Ultrasound

A transvaginal ultrasound is an imaging technique that utilizes sound waves to create detailed pictures of the reproductive organs, particularly the ovaries. A small wand-like device, called a transducer, is inserted into the vagina. The transducer emits sound waves, and the echoes create an image on a screen, enabling healthcare professionals to examine the ovaries’ structure and detect any abnormalities.

CA-125 Blood Test

The CA-125 blood test measures the levels of a protein called CA-125 in the blood, which can be elevated in the presence of certain cancers, including ovarian cancer. A blood sample is taken, and the concentration of CA-125 is analyzed. Elevated levels may indicate the need for further investigation into potential ovarian issues.

Diagnostic Imaging Techniques

Computed Tomography (CT) Scans

A CT scan is a powerful imaging tool that uses X-rays and computer technology to create detailed cross-sectional images of the body. For ovarian cancer diagnosis, CT scans are valuable for providing a comprehensive view of the pelvic region and abdomen. They can help identify the extent of the disease, detect abnormalities, and guide healthcare professionals in determining the most suitable treatment approach.

Magnetic Resonance Imaging (MRI)

 MRI is a non-invasive imaging technique that uses strong magnetic fields and radio waves to generate detailed pictures of the internal structures of the body. MRIs are particularly useful for assessing soft tissues and can provide additional information on the characteristics of tumors.

Positron Emission Tomography (PET) Scans

PET scans involve the injection of a small amount of radioactive material into the body, which is then detected by a special camera. This imaging technique is effective in revealing metabolic activity within tissues, aiding in the identification of areas with increased cell growth.

Confirmatory Procedures

Biopsy Procedures
  1. Fine-Needle Aspiration:
    • What it is: Using a thin needle to collect a small tissue sample from the ovarian mass.
    • How it helps: Helps identify cancer cells and determine the nature of the growth.
  2. Core Needle Biopsy:
    • What it is: Extracting a small, cylindrical tissue core with a slightly larger needle.
    • How it helps: Provides a more detailed sample, aiding in a precise diagnosis of the ovarian mass.
Exploratory Surgery (Laparoscopy or Laparotomy)

What it is: Directly observing the ovaries and nearby tissues through surgery.

  • Laparoscopy: Using a small camera through tiny incisions for a closer look.
  • Laparotomy: Making a larger incision for a more thorough examination.

Advanced Diagnostic Technologies

Liquid Biopsy

A liquid biopsy is a minimally invasive test that analyzes small fragments of DNA circulating in the blood. In ovarian cancer diagnosis, liquid biopsies can detect genetic mutations or alterations associated with cancer cells shed into the bloodstream. This allows healthcare professionals to monitor the progression of the disease and identify potential treatment targets without the need for invasive procedures.

Genetic Testing for Hereditary Factors

Genetic testing involves examining a person’s DNA to identify mutations or alterations that may increase the risk of developing ovarian cancer.  In the context of ovarian malignancy, certain genetic mutations, such as BRCA1 and BRCA2, are associated with a high risk of ovarian cancer. Genetic testing can help identify individuals with hereditary predispositions, allowing for proactive measures, such as increased surveillance or preventive interventions.

Wrapping Up

Keep an eye out for any strange signs, make those routine check-ups a habit, and if things seem a bit off, don’t be shy about diving deeper into these tests. Make sure to consult with your healthcare provider if you notice any symptoms as soon as possible!