Research indicates that Myfembree has demonstrated a notable reduction in heavy menstrual bleeding linked to uterine fibroids, with a reduction of up to 84% compared to a placebo.
It is prescribed for premenopausal individuals experiencing moderate to severe symptoms of uterine fibroids, including heavy menstrual bleeding and pelvic pain.
Let’s explore how Myfembree treatment works for those with heavy menstruation and uterine fibroids:
For whom is Myfembree Prescribed?
Myfembree, a once-daily oral tablet containing relugolix, estradiol, and norethindrone acetate, can be taken with or without food. Alongside treating heavy bleeding caused by fibroids, it is FDA-approved for alleviating pain associated with endometriosis. Myfembree aids in managing uterine fibroids through its combined action, with relugolix playing a pivotal role in lightening menstrual bleeding and reducing pain.
How Does Myfembree Aid in Managing Uterine Fibroids?
While each tablet of Myfembree contains three medications with distinct roles, the relugolix component primarily contributes to lightening menstrual bleeding and reducing pain associated with uterine fibroids.
Relugolix
Relugolix, categorized as a gonadotropin-releasing hormone (GnRH) antagonist, functions by attaching to particular receptors in the brain that are responsible for signaling the production of estrogen and progesterone, the primary hormones governing the menstrual cycle. By inhibiting these signals, relugolix reduces the production of estrogen and progesterone, resulting in decreased menstrual bleeding and alleviation of pain associated with conditions such as uterine fibroids.
Estradiol
Estradiol, a synthetic estrogen, may appear contradictory when taken alongside relugolix, which reduces natural estrogen levels. However, estradiol serves a crucial role in preventing potential side effects such as bone loss associated with decreased estrogen levels induced by relugolix. By providing the body with supplemental estrogen, estradiol helps maintain bone health despite the hormonal changes caused by relugolix.
Norethindrone Acetate
Norethindrone acetate, a synthetic progesterone known as progestin, may initially seem contradictory when combined with relugolix. However, when taking estrogen, such as estradiol, it’s essential also to include progestin. This combination mitigates the risk of developing endometrial (uterine) cancer, as estrogen alone can increase this risk. Progestins like norethindrone acetate serve to lower this risk, ensuring a balanced hormonal treatment approach.
Is There a Treatment Cure for Fibroids with Myfembree?
Myfembree demonstrates significant efficacy in alleviating menstrual bleeding and reducing pain associated with fibroids. Its effects are reversible, as observed in clinical trials where menstrual bleeding resumed approximately six weeks after discontinuation. It’s important to note that while Myfembree provides symptom relief, it does not actively shrink or cure fibroids.
The Bottom Line
Myfembree is beneficial for those experiencing symptoms associated with uterine fibroids. Through its combination of relugolix, estradiol, and norethindrone acetate, it has demonstrated effectiveness in reducing heavy menstrual bleeding, alleviating pelvic pain, and shrinking fibroid size.
Your healthcare practitioner will help you in navigating the treatment options, ensuring Myfembree is used appropriately and effectively to manage your symptoms. While not a cure for uterine fibroids, Myfembree, under the guidance of healthcare professionals, offers significant relief and represents a valuable treatment option for premenopausal individuals with moderate to severe symptoms.